Please use this identifier to cite or link to this item: http://rdu.iquimica.unam.mx/handle/20.500.12214/1306
Title: Wound healing activity of alpha pinene and alpha-phellandrene
Author: Manuel Jimenez_Estrada
Author ID: info:eu-repo/dai/mx/orcid/0000-0001-6187-4877
Contributor: María Margarita Canales-Martínez
Contributor's IDs: info:eu-repo/dai/mx/orcid/0000-0002-4292-0476
Abstract: Bursera morelensis is used in Mexican folk medicine to treat wounds on the skin. Recently, it was shown that the essential oil (EO) of B. morelensis has wound healing activity, accelerating cutaneous wound closure and generating scars with good tensile strength. α-pinene (PIN) and α-phellandrene (FEL) are terpenes that have been found in this EO, and it has been shown in different studies that both have anti-inflammatory activity. The aim of this study was to determine the wound healing activity of these two terpenes. The results of in vitro tests demonstrate that PIN and FEL are not cytotoxic at low concentrations and that they do not stimulate fibroblast cell proliferation. In vivo tests showed that the terpenes produce stress-resistant scars and accelerate wound contraction, due to collagen deposition from the early stages, in wounds treated with both terpenes. Therefore, we conclude that both α-pinene and α-phellandrene promote the healing process; this confirms the healing activity of the EO of B. morelensis, since having these terpenes as part of its chemical composition explains part of its demonstrated activity.
Issue Date: 2021
License: http://creativecommons.org/licenses/by/4.0
URI: http://rdu.iquimica.unam.mx/handle/20.500.12214/1306
metadata.dc.relation.alternativeidentifier: https://doi.org/10.3390/molecules26092488
Language: eng
Appears in Collections:Artículos

Files in This Item:
File Description SizeFormat 
Jimenez_EstradaM_Molecules_26_2488_2021.pdf4.87 MBAdobe PDFView/Open


Items in RI-IQUNAM are protected by copyright, with all rights reserved, unless otherwise indicated.