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Título: | Ascorbic acid as an aryl radical inducer in the gold-mediated arylation of indoles with aryldiazonium chlorides |
Autor: | PORCEL GARCIA, SUSANA |
ID del Autor: | info:eu-repo/dai/mx/cvu/391247 |
Resumen: | In recent years interest in the development of protocols that facilitate the oxidative addition of gold to access mild cross‐coupling processes mediated by this metal has increased. In this context, we report herein that ascorbic acid, a natural and readily accessible antioxidant, can be used to accelerate the oxidative addition of aryldiazonium chlorides onto AuI. The aryl–AuIII species generated in this way, has been used to prepare 3‐arylindoles in a one‐pot protocol starting from anilines and para‐, meta‐, and ortho‐ substituted aryldiazonium chlorides. The mechanism underlying the oxidative addition has been examined in detail based on EPR analyses, cyclic voltammetry, and DFT calculations. Interestingly, we have found that in this protocol, the chloride atom induces the AuII/AuIII oxidation step. |
Fecha de publicación: | 2020 |
Licencia: | http://creativecommons.org/licenses/by-nc-nd/4.0 |
URI: | http://rdu.iquimica.unam.mx/handle/20.500.12214/1218 |
metadata.dc.type.uri: | https://doi.org/10.1002/chem.201904413 |
Lenguaje: | eng |
Aparece en las colecciones: | Artículos |
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