http://rdu.iquimica.unam.mx/handle/20.500.12214/46 Fri, 13 Mar 2026 16:14:08 GMT 2026-03-13T16:14:08Z http://rdu.iquimica.unam.mx/handle/20.500.12214/1266 Title: Synthesis, structural characterization and antiproliferative activity on MCF-7 and A549 tumor cell lines of [Cu(N-N)(beta(3)-aminoacidate)] NO3 complexes (Casiopeinas (R) Author: Jonathan Román Valdéz-Camacho Contributor: Herbert Höpfl Abstract: The synthesis of three new mixed chelate copper (II) nitrate coordination compounds of the general formula {[Cu(phen)(L)(solv)NO3 center dot 0-0.5(solv)} is reported, where phen is 1,10-phenanthroline and L is a beta(3)-aminoacidate (beta-alaninate for 1, 3-aminobutanoate for 2 and 3-amino-3-cyclohexylpropanoate for 3), and the solvent (solv) is H2O and/or MeOH. The complexes were characterized by elemental analysis, IR and UV-Vis spectrophotometry, EPR spectroscopy, effective magnetic moment, conductometric and cyclovoltammetric measurements as well as single-crystal X-ray diffraction (SCXRD) analysis. All complexes are mononuclear Cu(II) complexes with d(9) configuration. In solution, the compounds are 1:1 electrolytes and exhibit square-based pyramidal coordination polyhedra. Meanwhile, in the solid state the coordination geometries are square-based pyramidal for compounds 1 and 2, but distorted octahedral for compound 3 due to coordination of the nitrate counterion. In vitro studies revealed that compounds 1, 2 and 3 have growth inhibition activity against MCF-7 and A549 tumor cell lines. The clustering of the experimental half-wave potential values among the three complexes could be explained by the fact of that the substitution pattern was changed on the secondary ligand, while the primary ligand remains without any structural modification. Wed, 01 Jan 2020 00:00:00 GMT http://rdu.iquimica.unam.mx/handle/20.500.12214/1266 2020-01-01T00:00:00Z http://rdu.iquimica.unam.mx/handle/20.500.12214/1264 Title: Experimental data on synthesis and characterization of chiral dinuclear manganese (II-II) compounds as biomimetic models of the active center of catalase Author: yenny patricia avila torres Abstract: Dinuclear manganese (II– III) compounds, which are potential models of the active center of catalase, were synthetized. This type of metalloenzymes presents biological importance due to three factors: they are redox catalyst centres, they are able to carry out hydrolytic reactions and they participate in activated processes via Lewis acids. Structurally, their active centre is composed by dinuclear manganese compounds, linked to nitrogen and oxygen donor atoms. An octahedral geometry around the metal ions were found, with acetate, hydroxy and aquo ligands; which can work as molecule bridges between them. The acid medium favours the electronic transfer between Mn3+ - Mn2+ as redox centre at 1.559 V and the consequent oxidation of hydrogen peroxide or organic molecules. The work also reports the data of two chiral novel compounds, [Mn2(S,S(+)Hcpse)4(NaClO4)2(NaOH)(CH4O)]n·[(C2H6O)2]n·[(CH4O)2]n and its respective enantioisomer, in which μ-oxo being as bridge metal centre. The X-ray structural was obtained as well as the optical and magnetic properties using Circular Dichroism, Electronic Paramagnetic Resonance, Magnetic Susceptibility and X-ray photoelectron spectroscopy. Wed, 01 Jan 2020 00:00:00 GMT http://rdu.iquimica.unam.mx/handle/20.500.12214/1264 2020-01-01T00:00:00Z http://rdu.iquimica.unam.mx/handle/20.500.12214/1232 Title: Generation of paramagnetic centers in carboxylatedmaterials via coordination attachment of diamagnetictetraazamacrocyclic complexes of nickel(II) Author: Virginia Gómez-Vidales Abstract: Coordination bonding of Ni(II) tetraazamacrocyclic (TAMC) complexes to car-boxylic groups of organic polymers and graphene oxide paper (GOP) is pro-posed for a facile generation of paramagnetic centers by combining twodiamagnetic components. The coordination functionalization occurs under basicconditions in water solution at room temperature. The coordination configura-tion of central Ni(II) changes from tetracoordinated square-planar to hexaco-ordinated pseudooctahedral, which implies the conversion from low-spin tohigh-spin nickel centers. In the case of organic polymers, the coordinationbonding of Ni(II) macrocycles gives rise to characteristic changes in coloration(from yellow-orange to violet-blue), as well as clearly manifests itself in UV–visible, FTIR and EPR spectra. In the case of GOP, in addition to evident changesin FTIR spectra, morphological alterations in the mat surface and an increase inthe mat thickness are observed in SEM images, which can be explained by anintercalating effect of voluminous macrocyclic cations, as well as by partialdisintegration of GOP structure due to the liquid-phase treatment. The effectivemagnetic moments of tetraazamacrocycles attached to organic polymers varyfrom 0.88 to 1.47 BM, whereas for GOP considerably higher values of 2.10 and 2.87 BM were obtained. Wed, 01 Jan 2020 00:00:00 GMT http://rdu.iquimica.unam.mx/handle/20.500.12214/1232 2020-01-01T00:00:00Z http://rdu.iquimica.unam.mx/handle/20.500.12214/1217 Title: Identification of intermediate compounds and photodegradation mechanisms of omeprazole under the system UV/O-2 Author: FRANCISCO JAVIER PEREZ FLORES Abstract: The photodegradation of the proton pump inhibitor omeprazole (OME) in aqueous media with the system UV/O2 is presented. The photodegradation rate was assessed by HPLC and UV‐vis spectroscopy, while the mineralization rate was obtained by TOC measurements. Degradation products were investigated by IR spectroscopy and GC‐MS analysis. UV‐vis absorbance and HPLC results indicated that OME is completely degraded within 3 minutes of irradiation. TOC analysis indicated that intermediates compounds are relatively easy to mineralize since 80% mineralization is achieved within 2 hours. IR studies demonstrated a rapid oxidation of OME leading to the formation of amines and both sulfonic and carboxylic acids. GC‐MS data indicated that the initial photoproducts are derivatives of both benzimidazole and pyridine produced after the photochemical cleavage of the C–S bond. Plausible mechanisms for the direct and indirect degradation of OME are given. In the photochemical degradation of OME, many intermediate compounds are actually generated. Several of them were generated from hydroxyl radical reactions, but some of them resulted from rearrangements, reductive reactions, and through the formation of highly reactive intermediates such as pseudo carbene, thiooxirane, and sulfenamide. Wed, 01 Jan 2020 00:00:00 GMT http://rdu.iquimica.unam.mx/handle/20.500.12214/1217 2020-01-01T00:00:00Z